The Click Chemistry Laboratory

The Moses Laboratory uses click chemistry to study biological systems at the molecular level. We develop and exploit powerful bond-forming click reactions that enable the rapid synthesis of small functional molecules, including cancer drugs and chemical probes. We apply these novel molecular tools in multidisciplinary discovery projects spanning the fields of biology and chemistry.

Select Publications

Phosphorus(V) Fluoride Exchange (PFEx): Multidimensional Click Chemistry from Phosphorus(V) Connective Hubs, Shoujun Sun, Joshua A. Homer, Christopher J. Smedley, Qing-Qing Cheng, K. Barry Sharpless, and John E. Moses,* Chem, 2023,

Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria, Alessandra Ottonello, Jessica A. Wyllie, Oussama Yahiaoui, Shoujun Sun. Rebecca A. Koelln, Joshua A. Homer, Robert M. Johnson, Ewan Murray, Paul Williams, Jani R. Bolla, Carol V. Robinson*, Thomas Fallon*, Tatiana P. Soares da Costa*, John E. Moses*, Proc. Natl. Acad. Sci. U.S.A., 2023, 120, e2208737120

Inhibition of Mitochondrial Metabolism by (–)-Jerantinine A: Synthesis and Biological Studies in Triple-Negative Breast Cancer Cells, Timothy L. Gialelis, Zifei Wang, Joshua A. Homer, Wen-Hsuan Yang, Taemoon Chung, Qingting Hu, Christopher J. Smedley, Nitin J. Pawar, Nitinkumar S. Upadhyay, David A. Tuveson, Scott K. Lyons, Michael J. Lukey, John E. Moses, RSC Med. Chem., 2023, 14, 710 – 714