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    Organic, Biomolecular and Click Chemistry Research Group

Latest Publications

Giel M.-C., Barrow A.S., Smedley C.J., Lewis W., Moses J.E., Aminium cation-radical catalysed selective hydration of (E)-aryl enynes, ChemComm., 2021, doi: 10.1039/d1cc02257a. Epub ahead of print. PMID: 34159967.

Smedley, C.J., Li, G., Barrow, A. S., Gialelis, T. L., Giel, M.-C., Ottonello, A., Cheng, Y., Kitamura, S., Wolan, D. W., Sharpless, K. B. and Moses, J. E., Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs,  Angew. Chem. Int. Ed., 2020DOI:10.1002/anie.202003219

Giel, M.-C., Smedley, C. J., Mackie, E. R. R., Guo, T., Dong, J., Soares da Costa, T. P. and Moses, J. E., Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides, Angew. Chem. Int. Ed., 2020, 59, 1181, DOI:10.1002/anie.201912728

Zheng, Q., Woehl, J. L., Kitamura, S., Santos-Martins, D., Smedley, C. J., Li, G., Forli, S., Moses, J. E., Wolan, D. W. and Sharpless, K. B., SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase, Proc. Natl. Acad. Sci. U.S.A., 2019, 116, 18808, DOI:10.1073/pnas.1909972116

Barrow, A. S., Smedley, C. J., Zheng, Q., Li, S., Dong, J. and Moses, J. E., The growing applications of SuFEx click chemistry, Chem. Soc. Rev., 2019, 48, 4731, DOI:10.1039/C8CS00960K

Liu, F., Wang, H., Li, S., Bare, G. A. L., Chen, X., Wang C., Moses J. E., Wu, P. and Sharpless, K. B., Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins, Angew. Chem. Int. Ed., 201958, 8029, DOI:10.1002/anie.201902489

Smedley, C. J., Zheng, Q., Gao, B., Li, S., Molino, A., Duivenvoorden, H. M., Parker, B. S., Wilson, D. J. D.,  Sharpless, K. B. and Moses, J. E., Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides, Angew. Chem. Int. Ed., 201958, 4552, DOI:10.1002/anie.201813761

Randall, J. D., Eyckens, D. J., Stojcevski, F., Francis, P. S., Doeven, E. H., Barlow, A. J., Barrow, A. S., Arnold, C. L., Moses, J. E. and Henderson, L. C., Modification of Carbon Fibre Surfaces by Sulfur-Fluoride Exchange Click Chemistry, ChemPhysChem, 2018, 19, 3176, DOI:10.1002/cphc.201800789

Smedley, C. J., Stanley P. A., Qazzaz, M. E., Prota, A. E., Olieric, N., Collins, H., Eastman, H., Barrow, A. S., Lim, K.-H., Kam, T.-S., Smith, B. J., Duivenvoorden, H. M., Parker, B. S., Bradshaw, T. D., Steinmetz, M. O. and Moses, J. E., Sustainable Syntheses of Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site, Sci. Rep., 2018, 8, 10617, DOI:10.1038/s41598-018-28880-2

Sharma, P., Bhat, S., Prabhath, R. M. R.,Molino, A., Nauha, E., Wilson, D. J. D. and Moses, J. E., Synthesis of 1,2,4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-Cyanamides, Org. Lett., 2018, 20, 4263, DOI:10.1021/acs.orglett.8b01673 

Gahtory, D., Sen, R., Pujari, S., Li, S., Zheng, Q., Moses, J. E., Sharpless, K. B. and Zuilhof, H., Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms, Chem. Eur. J., 201824, 10550, DOI:10.1002/chem.201802356

Smedley, C. J., Giel, M.-C., Molino, A., Barrow, A. S., Wilson, D. J. D. and Moses, J. E., 1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry, Chem. Commun., 201854, 6020, DOI:10.1039/c8cc03400a

Jenner, M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., Moses, J. E., Oldham, N. J., Lewandowski, J. R. and Challis, G. L., Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases, Nat. Chem. Bio., 201814, 270. DOI:10.1038/nchembio.2549

Gao, B., Li, S., Wu, P., Moses, J. E. and Sharpless K. B., SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides and Sulfonimidates, Angew. Chem. Int. Ed.2018, 57, 1939. DOI:10.1002/ange.201712145

Powell, K. J., Richens, J. L., Bramble, J. P., Han L. -C., Sharma, P., O’Shea P. and Moses, J. E., Photochemical activity of membrane-localised polyketide derived marine natural products, Tetrahedron2017, 74, 1191. Invited special edition highlighting chemical biology in Australia. DOI:10.1016/j.tet.2017.10.056