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“My group uses click chemistry to study biological systems at the molecular level. We develop and exploit powerful bond-forming click reactions that enable the rapid synthesis of small functional molecules, including cancer drugs and chemical probes. We apply these novel molecular tools in multidisciplinary discovery projects spanning the fields of biology and chemistry.” – John Moses

IMG_6583Special Feature – June 2021

This week has been a fruitful one for the newly forged chemistry department at Cold Spring Harbor Laboratory. Following the announcement of Prof. John Moses’s win of the RSC 2021 Organic Division Horizon Prize, postdoctoral fellow Dr. Joshua Homer of the Moses Laboratory has been awarded a grant by the New York Community Trust to support his endeavors in the development of new and improved leprosy treatments.

The Heiser program, established by the will of Dr. Victor Heiser, an American physician and researcher who spent his professional life studying and caring for people with leprosy, provides fellowships for early-career researchers as well as seminal research projects led by senior scientists to improve the diagnosis and treatment of leprosy. Dr. Joshua Homer will use state-of-the-art modular click-chemistry techniques to develop and test unprecedented numbers of novel drug analogues to improve on the current front-line treatments and explore unexplored therapeutic space.

This work will be conducted primarily at Cold Spring Harbor Laboratory, where the merger between chemistry and biology will allow for this ground-breaking work to flourish. With mentorship from Prof. John Moses (CSHL), a world-leader in the field of click chemistry, and collaboration with Dr. Ramanuj Lahiri at the National Hansen’s Disease Program, Louisiana, an expert in leprosy infections, the new drugs developed from this work will change the lives of those affected by this debilitating disease.

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Winner: 2021 Organic Division Horizon Prize:
Robert Robinson Award in Synthetic Organic Chemistry

June 2021

For the development of multidimensional click chemistry, a next-generation click-technology that      extends bond creation into the three-dimensional world, opening doors to new frontiers in biomedicine, materials science, and beyond.

Combining Chemistry and Biology at CSHLCombining Chemistry and Biology at CSHL

October 1, 2020

Professor John Moses joins the CSHL faculty, specializing in the field of click chemistry.

Screen Shot 2021-06-01 at 4.00.44 PMCold Spring Harbor Laboratory to open first chemistry lab in its 130-year history

October 2020

Renowned molecular biology institute is bringing click chemistry to drug discovery